Xavier Capaldi


I am a software developer working at Optable in Montréal, Québec. I completed my M.Sc. in physics under the tutelage of Professor Walter Reisner on the topic of nanoconfined polymers. I developed and fabricated nanofluidic devices with pneumatically-actuated membranes capable of trapping multiple DNA molecules in nanoscale cavities. You can see my publications and projects listed below.

Publications

Tunable nanofluidic device for digital nucleic acid analysis (2024)
- This article appeared in Nanoscale, 19 (2024) and may be found at https://pubs.rsc.org/en/content/articlelanding/2024/nr/d3nr05553a.
Transient physics in the compression and mixing dynamics of two nanochannel-confined polymer chains (2024)
- This article appeared in Phys. Rev. E 109, 024501 (2024) and may be found at https://journals.aps.org/pre/abstract/10.1103/PhysRevE.109.024501.
Characterizing interaction of multiple nanocavity confined plasmids in presence of large DNA model nucleoid (2023)
- This article appeared in Soft Matter, 19 (2023) and may be found at https://pubs.rsc.org/en/content/articlelanding/2023/sm/d3sm00491k.
Confinement anisotropy drives polar organization of two DNA molecules interacting in a nanoscale cavity (2022)
- This article is released under a Creative Commons Attribution 4.0 International License and thus may be downloaded here.
- This article appeared in Nature Communications. 13, (2022) and may be found at https://www.nature.com/articles/s41467-022-31398-x.
Nanofluidics for simultaneous size and charge profiling of extracellular vesicles (2021)
- This article appeared in Nano Lett. ASAP, (2021) and may be found at https://pubs.acs.org/doi/10.1021/acs.nanolett.0c02558. Copyright © 2021 by American Chemical Society.
High osmotic power generation via nanopore arrays in hybrid hexagonal boron nitride/silicon nitride membranes (2021)
- This article appeared in Nano Lett. 21, 4152-4159 (2021) and may be found at https://pubs.acs.org/doi/10.1021/acs.nanolett.0c04704. Copyright © 2021 by American Chemical Society.
Time-dependent knotting of agitated chains (2021)
- This article appeared in Phys. Rev. E 103, 032501 (2021) and may be found at https://journals.aps.org/pre/abstract/10.1103/PhysRevE.103.032501. Copyright © 2021 by APS.
An apparatus based on an atomic force microscope for implementing tip-controlled local breakdown (2019)
- This article may be downloaded for personal use only. Any other use requires permission of the author and AIP Publishing.
- This article appeared in Review of Scientific Instruments 90, 123703 (2019) and may be found at https://aip.scitation.org/doi/10.1063/1.5129665.
Nanopore formation via tip-controlled local breakdown using an atomic force microscope (2019)
- Access the manuscript from the publisher here.
- See the cover graphic.
On the biomechanics of cardiac s-looping in the chick: insights from modeling and perturbation studies (2019)
- This article may be downloaded for personal use only. Copyright © 2019 by ASME.
From 2D to 3D: Graphene molding for transparent and flexible probes (2019)
- This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing.
- This article appeared in Appl. Phys. Lett. 114, 043301 (2019) and may be found at https://aip.scitation.org/doi/abs/10.1063/1.5075618?journalCode=apl.
Probing the organization and dynamics of two DNA chains trapped in a nanofluidic cavity (2018)
- Access the manuscript from the publisher here.
- See the cover graphic.
Masters thesis (2018): Nanofluidic device for active variation of confinement using pneumatically actuated flexible nanoscale membranes
- Read my thesis.
Honors undergraduate thesis (2016)
- Read my thesis.

Projects

NanoPrep (2022)
- nanopore formation, growth, conditioning and characterization using a PyMeasure interface with a Keithley 2400 Sourcemeter.
fondle notification daemon (2021)
- minimal, hackable notification daemon designed for lightweight window managers or the terminal.
KOH etch and nanopore size calculators (2020)
- javascript calculator for silicon and silicon dioxide etch rates in hot KOH.
- javascript calculator for estimating nanopore sizes from IV curves.
Terminal Braid Knotting Model [tbkm] (2020)
- generate and analyze knots generated directly in the terminal with box-drawing characters.
DIY Arduino Uno (2019)
- designed and fabricated a board to support the Atmega328P microcontroller with nearly full Uno functionality.
Whyknot (2019)
- Tkinter-based gui which facilitates the drawing (and analysis) of 3D knot schematics.
Multicrop for ImageJ/Fiji (2019)
- set of three small jython packages which allow the selection of multiple regions, cropping those selections and splitting color channels. Designed to facilitate preprocessing of fluorescence microscopy data.
Noise subtraction for ImageJ/Fiji (2019)
- jython package to apply Tang/Doyle background subtraction algorithm to fluorescence microscopy data.